Biomarkers Which Inform Treatment

Searching for Qualitative Interactions

The next stage of our research is to search for clinically relevant predictive biomarkers. The NCBI Gene Expression Omnibus is a public repository which offers free access to data from several promising randomized clinical trials with gene expression measurements. We are also requesting permission to run our method on RCT data which include results from GenomicHealth Oncotype DX diagnostic breast cancer tests. Oncotype DX assays use the expression levels of multiple genes to construct a biomarker with excellent predictive power (which we hope to improve further on). Since our method is independently run on one gene at a time, our computing task is easily parallelizable and is an excellent fit for Amazon EC2.